Figure 2: Effects of the β1blocker, metoprolol and α1- blocker, doxazosinon CAVI and baPWV [20]. When selective β1 adrenergic blocker metoprolol (80 mg) was administered, both systolic and diastolic blood pressures decrease and baPWV also decreases, but CAVI does not change [20] (Figure 2A). This study indicates that CAVI is independent of blood pressure at the time of measurement. Furthermore, with the administration of selective α1-aderenergic receptor blocker, doxazosin, both systolic and diastolic blood pressures decreased and CAVI decreased as well as baPWV (Figure 2B), indicating that CAVI decreased with a relaxation of smooth muscles induced by α1-aderenergic receptor blocker.