| Endpoint |
|
|
|
0 variants |
1 variant |
2 variants |
p-trend* |
|
|
|
| Primary |
| Duke CAD Index |
|
|
42.4 ± 16.1 |
44.0 ± 17.4 |
47.4 ± 17.6 |
0.11 |
|
|
|
|
| Secondary: CAD Index Components |
| Number of Lesions |
|
|
2.5 ± 1.9 |
2.7 ± 2.1 |
2.8 ± 2.0 |
0.11 |
|
|
|
|
| Maximum Stenosis |
|
|
95.2 ± 7.5 |
95.3 ± 7.6 |
95.6 ± 7.2 |
0.89 |
|
|
|
|
| Number of Proximal+LM Lesions |
0.56 ± 0.69 |
0.62 ± 0.74 |
0.71 ± 0.77 |
0.0055† |
|
|
|
|
|
|
| Ostial Lesions |
|
|
|
2.50% |
|
4.20% |
|
4.50% |
|
0.17 |
| Left Main Lesions |
|
|
2.00% |
|
4.00% |
|
3.90% |
|
0.18 |
|
| Proximal RCA Lesions |
|
25.10% |
|
24.70% |
|
32.30% |
|
0.01 |
|
|
| Proximal LAD Lesions |
|
21.40% |
|
25.70% |
|
24.30% |
|
0.37 |
|
|
| Proximal LCx Lesions |
|
7.30% |
|
8.00% |
|
10.40% |
|
0.09 |
|
|
*Adjusted in analysis of variance or logistic regression for age, sex, BMI, hypertension, hyperlipidemia, smoking, and family history of early CHD; †Secondary endpoint
significant after correction for multiple comparisons (p ≤ 0.0056 [0.05 / 9 tests]) |
