Endpoint       0 variants 1 variant 2 variants p-trend*      
Primary
Duke CAD Index     42.4 ± 16.1 44.0 ± 17.4 47.4 ± 17.6 0.11        
Secondary: CAD Index Components
Number of Lesions     2.5 ± 1.9 2.7 ± 2.1 2.8 ± 2.0 0.11        
Maximum Stenosis     95.2 ± 7.5 95.3 ± 7.6 95.6 ± 7.2 0.89        
Number of Proximal+LM Lesions 0.56 ± 0.69 0.62 ± 0.74 0.71 ± 0.77 0.0055†            
Ostial Lesions       2.50%   4.20%   4.50%   0.17
Left Main Lesions     2.00%   4.00%   3.90%   0.18  
Proximal RCA Lesions   25.10%   24.70%   32.30%   0.01    
Proximal LAD Lesions   21.40%   25.70%   24.30%   0.37    
Proximal LCx Lesions 7.30% 8.00% 10.40% 0.09
*Adjusted in analysis of variance or logistic regression for age, sex, BMI, hypertension, hyperlipidemia, smoking, and family history of early CHD; †Secondary endpoint significant after correction for multiple comparisons (p ≤ 0.0056 [0.05 / 9 tests])
Table 2: Average Duke CAD Index (mean ± SD) and the means or proportions of its component CAD burden measures by rs1333049 among non-diabetics with CAD (N=1,757).