# of rs1333049 Variants   Coronary Disease     0 1 2 p-trend Significant 3-, 2-, or 1-vessel CAD (N=1,757)             3-vessel CAD (n=349) 19% 45% 36%   0.0017   2-vessel CAD (n=471) 23% 51% 26%       1-vessel CAD (n=937) 24% 51% 25%       All non-diabetics: Significant CAD (3-, 2-, or 1-vessel) and 0-vessel (mild/no) disease (N=3,363)             3-vessel CAD (n=349) 19% 45% 36%   9.0 x 10-9   2-vessel CAD (n=471) 23% 51% 26%       1-vessel CAD (n=937) 24% 51% 25%         0-vessel CAD (n=1,606) 27% 52% 21%

Table 3: Genotype distributions for non-diabetic patients among CAD patients stratified by 3-, 2-, and 1-vessel CAD and among all CAD and no-CAD patients by 3-, 2-, 1-, and 0-vessel disease.