Pro-atheroscleotic genes Effect of Ang II
monocyte chemotactic protein-1 (MCP-1) upregulation
macrophage-colony stimulating factor (M-CSF) upregulation
endothelial-selectin (E-selectin) upregulation
intercellular adhesion molecule-1 (ICAM-1) upregulation
vascular cell adhesion molecule-1 (VCAM-1) upregulation
inducible nitric oxide synthase (iNOS) upregulation
cyclooxygenase-2 (COX-2) upregulation
tumor necrosis factor-α (TNF-α) upregulation
interleukin-6 (IL-6) upregulation
interleukin-1β (IL-1β) upregulation
transforming growth factor β1 (TGF-β1) upregulation
regulated upon Activation, Normal T cell Expressed and Secreted (RANTES) upregulation
monocyte chemoattractant protein-1 (MCP-1) upregulation
C-C chemokine receptor type 1 (CCR1) upregulation
C-C chemokine receptor type 2 (CCR2) upregulation
C-C chemokine receptor type 3 (CCR3) upregulation
granulocyte colony-stimulating factor (G-CSF) upregulation
granulocyte macrophage colony-stimulating factor (GM-CSF) upregulation
interleukin-12 IL-12 (P40) upregulation
macrophage inflammatory protein 1-α (MIP-1α) upregulation
interferon-γ (IFN-γ) upregulation
Anti-atheroscleotic genes Effect of Ang II
peroxisome proliferator-activated receptor-α (PPAR-α) downregulation
peroxisome proliferator-activated receptor-γ (PPAR-γ) downregulation
Table 1: Effects of Angiotensin II on pro-atherosclerotic and anti-atherosclerotic genes expression in mouse aorta [16,20,21].