Alleles

CC

CT

P value

Rejection episodes

+ (%)

+ (%)

 

0 (N=14)*

3 (21.4)

11 (78.6)

<0.007

0-1(N=27)

12 (44.4)

15(55.6)

NS

1-2(N=31)

23 (74.2)

8 (25.8)

<0.0001a

2 (N=18)

14 (77.8)

4 (22.2)

<0.002b

2-3(N=29)

23 (79.3)

6 (20.7)

<0.0001c

≥4 (N=12)*

10 (83.3)

2 (16.7)

<0.003d

a: Odds Ratio (OR)=8.26 (95% CI; 2.3-30.9); b: OR= 12.25 (95% CI; 2.05-85.6); c:OR=14.69 (95% CI; 3.5-66.35); d: OR=25.0 (95% CI; 2.16-484.8).
*: Individuals carrying CT alleles were compared in those with 0 rejection episode vs. ≥4 grade 3R cellular rejection episodes within the first 6 months after transplantation (p<0.005; OR=18.3; 95% CI; 1.92-247.02).
Table 2: AIF-1 allele frequency association with rejection episode patterns with the first 6 months after cardiac transplantation.