Figure 1: Demonstrates the Calcific Aortic Valve Disease: Cellular Origins of Valves Calcification and the mechanisms of osteogensis in these cell types. Panel A: The potential cellular phenotypes for mesenchymal derived cells, Panel B: The two different cell origins for valve calcification: the COP cell versus the native interstitial cell both contributing to the hypothesis of osteogenesis in calcific aortic valve disease [65].