Figure 1: The schematic representation of our working model. Several cardiovascular risk factors induce pro-inflammatory signaling pathway inducing T cells activation. T effector cell activation promotes pro-inflammatory cytokines leading to break-down of immune tolerance and finally autoimmune disease. In contrast, Enhance Tregs expansion and function inhibits Atherosclerosis by maintaining immune tolerance. Suppression of Teff and others immune cells by Treg is proposed in 5 mechanisms: Cell-Cell contact, Granzymes, Suppressive Cytokines, Adenosine and micro RNA. Vitamin D3, Statins and IL-2 are new therapeutic targets that promote Treg survival and homeostasis in order to maintain the balance in the immune system.