| Location |
Mapped genes |
SNP(s) |
Risk allele frequency - controls |
P-value |
OR (95% CI) |
Gene function
(known or probable?) |
Disease |
References |
| 1p13.3 |
CELSR2, PSRC1, SORT1 |
rs599849
rs646776
rs599839 |
0.77
0.81
0.78 |
4 x 10-9
8 x 10-12
3 x 10-10 |
1.29(1.18-1.40)
1.19 (1.13-1.26)
1.11 (1.08-1.15) |
LDL |
CAD
MI
CAD |
[32]
[39]
[16] |
| 1p32.2 |
PPAP2B |
rs17114046
rs17114036 |
NR
0.91 |
2 x 10-7
4 x 10-19 |
NR
1.17 (1.13-1.22) |
Lipid phosphate phosphatase-3 |
CAD
CAD |
[43]
[16] |
| 1p32.3 |
PCSK9 |
rs11206510
rs11206510 |
0.81
0.82 |
1 x 10-8
9 x 10-8 |
1.15 (1.10-1.21)
1.08 (1.05-1.11) |
LDL |
MI
CAD |
[39]
[16] |
| 1q21.3 |
ILR6 |
rs2229238 |
NA |
7 x 10-7 |
1.45 (NR) |
IL-6 receptor |
|
[40] |
| 1q41 |
MIA3 |
rs17465637
rs17465637
rs17465637 |
0.71
0.72
0.74 |
1 x 10-6
1 x 10-9
1 x 10-8 |
1.2 (1.12-1.30)
1.14 (1.10-1.19)
1.14 (1.09-1.20) |
Collagen processing |
CAD
MI
CAD |
[32]
[39]
[16] |
| 2p21 |
ABCG8 |
rs4299376 |
0.29 |
|
1.09 |
Lipids |
CAD |
[45] |
| 2q32.1 |
TFP1 |
rs7586970 |
NR |
9 x 10-6 |
NR |
Unknown |
CAD |
[43] |
| 2q33.2 |
WDR12 |
rs6725887
rs6725887 |
0.14
0.15 |
1 x 10-8
1 x 10-8 |
1.17 (1.11-1.23)
1.14 (1.09-1.19) |
Apoptosis |
MI
CAD |
[39]
[16] |
| 2q35 |
FN1 |
rs17458018 |
NA |
7 x 10-6 |
1.22 (NR) |
Fibronectin |
|
[40] |
| 2q36.3 |
KIAA1486 |
rs2943634 |
0.65 |
2 x 10-7 |
1.21 (1.13-1.30) |
Unknown |
CAD |
[32] |
| 2q37.1 |
INPP5D |
rs10933436 |
0.49 |
7 x 10-6 |
1.06 (1.04-1.09) |
Hematopoiesis |
CAD |
[16] |
| 3p25.1 |
BTD |
rs7651039 |
0.54 |
2 x 10-6 |
1.06 (1.04-1.09) |
Biotinidase |
CAD |
[16] |
| 3q22.3 |
MRAS |
rs9818870
rs2306374 |
0.15
0.18 |
7 x 10-13
3 x 10-8 |
1.15 (1.11-1.19)
1.12 (1.07-1.16) |
Adhesion signaling |
CAD |
[41]
[16] |
| 4q31.22 |
TTC29 – RPL31P26 |
rs1395821 |
NR |
7 x 10-7 |
NR |
Unknown |
CAD |
[43] |
| 5q31.1 |
IL5 |
rS2706399 |
0.48 |
|
1.02 |
Interleukin 5 |
CAD |
[45] |
| 6p21.1 |
VEGFA |
rs6905288 |
NR |
7 x 10-8 |
1.23 (NR) |
Angiogenesis |
|
[40] |
| 6p21.31 |
ANKS1A |
rs17609940 |
0.75 |
1 x 10-8 |
1.07 (1.05-1.10) |
Immune system |
CAD |
[16] |
| 6p21.33 |
HCG27, HLA-C |
rs3869109 |
NR |
1 x 10-9 |
1.14 (NR) |
Unknown |
|
[40] |
| 6p24.1 |
PHACTR1 |
rs12526453
rs9349379
rs12526453 |
0.65
NR
0.67 |
1 x 10-9
9 x 10-26
1 x 10-9 |
1.12 (1.08-1.17)
NR
1.1 (1.06-1.13) |
Coronary calcification |
MI
CAD
CAD |
[39]
[43]
[16] |
| 6q14.1 |
FAM46A - IBTK |
rs16893526 |
0.91 |
5 x 10-6 |
1.13 (1.07-1.21) |
Unknown |
CAD |
[44] |
| 6q16.1 |
FHL5 |
rs12200560 |
NR |
6 x 10-7 |
1.11 (NR) |
Transcriptional activation |
CAD |
[40] |
| 6q23.2 |
TCSF21 |
rs12190287 |
0.62 |
1 x 10-12 |
1.08 (1.06-1.10) |
Tumor suppressor |
CAD |
[16] |
| 6q25.1 |
MTHFD1L |
rs6922269 |
0.25 |
3 x 10-8 |
1.23 (1.15-1.33) |
Tetrahydrofolate synthesis |
CAD |
[32] |
| 6q25.3 |
LPA |
rs3798220 |
0.02 |
3 x 10-11 |
1.51 (1.33-1.70) |
Lipoprotein (a) |
CAD |
[16] |
| 6q25.3 |
FNDC1 |
rs365302 |
0.24 |
8 x 10-7 |
1.11 (1.06-1.15) |
Unknown |
CAD |
[44] |
| 7q22.3 |
BCAP29 |
rs10953541 |
0.80 |
3 x 10-8 |
1.08 (1.05-1.11) |
Unknown |
|
[43] |
| 7q31.2 |
ASZ1 |
rs7808424 |
0.12 |
1 x 10-6 |
1.1 (1.06-1.14) |
Unknown |
CAD |
[16] |
| 7q32.2 |
ZC3HC1 |
rs11556924 |
0.62 |
9 x 10-18 |
1.09 (1.07-1.12) |
Unknown |
CAD |
[16] |
| 8q24.13 |
TRIB1 |
rs10808546 |
0.65 |
|
1.04 |
Lipids |
CAD |
[45] |
| 9p21.3 |
ANRIL/CDKN2BAS CDKN2A, CDKN2B |
rs1333049
rs4977574
rs4977574
rs4977574
rs1333049 |
0.47
0.56
NR
0.46
0.49 |
3 x 10-19
3 x 10-44
2 x 10-25
1 x 10-22
7 x 10-58 |
1.36 (1.27-1.46)
1.29 (1.25-1.34)
1.20 (1.16-1.25)
1.29 (1.23-1.36)
1.27 (1.23-1.31) |
Regulatory functions? |
CAD
MI
CAD
CAD
CAD |
[32]
[39]
[43]
[16]
[44] |
| 9q22.33 |
HEMGN – ANP32B |
rs4743150 |
NR |
5 x 10-6 |
NR |
Unknown |
CAD |
[43] |
| 9q34.2 |
ABO |
rs514659
rs579459 |
0.37
0.21 |
8 x 10-9
4 x 10-14 |
1.21 (1.13-1.28)
1.10 (1.07-1.13) |
Coronary thrombosis |
CAD/MI
CAD |
[17]
[16] |
| 10p11.23 |
KIAA1462 |
rs3739998
rs2505083 |
0.44
0.38 |
1 x 10-11
4 x 10-8 |
1.15 (1.11-1.20)
1.07 (1.04-1.09) |
Endothelial cell adhesion |
CAD
CAD |
[42]
[43] |
| 10q11.21 |
CXCL12 |
rs501120
rs1746048
rs1746048 |
0.87
0.84
0.87 |
9 x 10-8
7 x 10-9
3 x 10-10 |
1.33 (1.20-1.48)
1.17 (1.11-1.24)
1.09 (1.07-1.13) |
Platelet aggregation? |
CAD
MI
CAD |
[32]
[39]
[16] |
| 10q23.31 |
LIPA |
rs1412444
rs1412444 |
0.42
0.32 |
3 x 10-13
4 x 10-8 |
1.09 (1.07-1.12)
1.1 (1.07-1.14) |
Lipids |
CAD |
[43]
[44] |
| 10q24.32 |
CNNM2 |
rs12413409
rs12413409 |
NR
0.89 |
4 x 10-6
1 x 10-9 |
NR
1.12 (1.08-1.16) |
Mg homeostasis? |
CAD
CAD |
[43]
[16] |
| 11q22.3 |
PDGFD |
rs974819 |
0.32 |
2 x 10-9 |
1.07 (1.04-1.09) |
Smooth muscle cell proliferation |
CAD |
[43] |
| 11q23.3 |
ZNF259 |
rs964184 |
0.13 |
1 x 10-17 |
1.13 (1.10-1.16) |
Unknown |
CAD |
[16] |
| 11q24.2 |
ST3GAL4 |
rs4937126 |
0.69 |
5 x 10-6 |
1.06 (1.04-1.09) |
Protein glycosylation |
CAD |
[16] |
| 12q24.12 |
SH2B3 |
rs3184504 |
0.44 |
6 x 10-6 |
1.07 (1.04-1.10) |
Hematopoiesis |
CAD |
[16] |
| 12q24.31 |
HFN1A |
rs2259816 |
0.36 |
5 x 10-7 |
1.08 (1.05-1.11) |
Transcription factor |
CAD |
[41] |
| 13q34 |
COL4A1-A2 |
rs4773144 |
0.44 |
4 x 10-9 |
1.07 (1.05-1.09) |
Type IV collagen |
CAD |
[16] |
| 14q32.2 |
HHIPL1 |
rs2895811 |
0.43 |
1 x 10-10 |
1.07 (1.05-1.10) |
Unknown |
CAD |
[16] |
| 15q22.33 |
SMAD3 |
rs17228212 |
0.30 |
2 x 10-7 |
1.21 (1.13-1.30) |
Transcriptional modulator |
CAD |
[32] |
| 15q25.1 |
ADAMTS7 |
rs1994016
rs43800028
rs3825807 |
0.60
0.65
0.57 |
5 x 10-13
4 x 10-9
1 x 10-12 |
1.19 (1.13-1.24)
1.07 (1.05-1.10)
1.08 (1.06-1.10) |
Migration of vascular smooth muscle cells |
CAD
CAD
CAD |
[17]
[43]
[16] |
| 15q24.1 |
CYP1A1 – CYP1A2 |
rs2472299 |
|
3 x 10-6 |
NR |
Lipid synthesis? |
CAD |
[43] |
| 17q12 |
ACCN1 |
rs11650066 |
NR |
6 x 10-6 |
NR |
Sodium channel? |
CAD |
[43] |
| 17p13.3 |
SMG6 |
rs216172 |
0.37 |
1 x 10-9 |
1.07 (1.05-1.09) |
Telomerase ribonucleoprotein complex |
CAD |
[16] |
| 17p11.2 |
PEMT |
rs12936587 |
0.56 |
4 x 10-10 |
1.07 (1.05-1.09) |
Choline metabolism |
CAD |
[16] |
| 17q21.32 |
UBE2Z |
rs46522 |
0.53 |
2 x 10-8 |
1.06 (1.04-1.08) |
Apoptosis? |
CAD |
[16] |
| 17q23.3 |
PECAM1 |
rs6504218 |
NR |
1 x 10-6 |
NR |
Angiogenesis? |
CAD |
[43] |
| 19p13.2 |
LDLR |
rs1122608
rs1122608 |
0.75
0.77 |
2 x 10-9
1 x 10-9 |
1.15 (1.10-1.20)
1.14 (1.09-1.18) |
LDL |
MI
CAD |
[39]
[16] |
| 19q13.2 |
APOE |
rs2075650 |
0.14 |
|
1.14 |
LDL |
CAD |
|
| 21q22.11 |
MRPS6, KCNE2 |
rs9982601
rs9982601 |
0.13
0.15 |
6 x 10-11
4 x 10-10 |
1.20 (1.14-1.27)
1.18 (1.12-1.24) |
Voltage gated potassium channel |
MI
CAD |
[39]
[16] |
| Xq23 |
CHRDL1 |
rs5943057 |
NR |
9 x 10-7 |
NR |
Angiogenesis? |
CAD |
[43] |
