Location Mapped genes SNP(s) Risk allele frequency - controls P-value OR (95% CI) Gene function
(known or probable?)
Disease References
1p13.3 CELSR2, PSRC1, SORT1 rs599849
rs646776
rs599839
0.77
0.81
0.78
4 x 10-9
8 x 10-12
3 x 10-10
1.29(1.18-1.40)
1.19 (1.13-1.26)
1.11 (1.08-1.15)
LDL CAD
MI
CAD
[32]
[39]
[16]
1p32.2 PPAP2B rs17114046
rs17114036
NR
0.91
2 x 10-7
4 x 10-19
NR
1.17 (1.13-1.22)
Lipid phosphate phosphatase-3 CAD
CAD
[43]
[16]
1p32.3 PCSK9 rs11206510
rs11206510
0.81
0.82
1 x 10-8
9 x 10-8
1.15 (1.10-1.21)
1.08 (1.05-1.11)
LDL MI
CAD
[39]
[16]
1q21.3 ILR6 rs2229238 NA 7 x 10-7 1.45 (NR) IL-6 receptor   [40]
1q41 MIA3 rs17465637
rs17465637
rs17465637
0.71
0.72
0.74
1 x 10-6
1 x 10-9
1 x 10-8
1.2 (1.12-1.30)
1.14 (1.10-1.19)
1.14 (1.09-1.20)
Collagen processing CAD
MI
CAD
[32]
[39]
[16]
2p21 ABCG8 rs4299376 0.29   1.09 Lipids CAD [45]
2q32.1 TFP1 rs7586970 NR 9 x 10-6 NR Unknown CAD [43]
2q33.2 WDR12 rs6725887
rs6725887
0.14
0.15
1 x 10-8
1 x 10-8
1.17 (1.11-1.23)
1.14 (1.09-1.19)
Apoptosis MI
CAD
[39]
[16]
2q35 FN1 rs17458018 NA 7 x 10-6 1.22 (NR) Fibronectin   [40]
2q36.3 KIAA1486 rs2943634 0.65 2 x 10-7 1.21 (1.13-1.30) Unknown CAD [32]
2q37.1 INPP5D rs10933436 0.49 7 x 10-6 1.06 (1.04-1.09) Hematopoiesis CAD [16]
3p25.1 BTD rs7651039 0.54 2 x 10-6 1.06 (1.04-1.09) Biotinidase CAD [16]
3q22.3 MRAS rs9818870
rs2306374
0.15
0.18
7 x 10-13
3 x 10-8
1.15 (1.11-1.19)
1.12 (1.07-1.16)
Adhesion signaling CAD [41]
[16]
4q31.22 TTC29 – RPL31P26 rs1395821 NR 7 x 10-7 NR Unknown CAD [43]
5q31.1 IL5 rS2706399 0.48   1.02 Interleukin 5 CAD [45]
6p21.1 VEGFA rs6905288 NR 7 x 10-8 1.23 (NR) Angiogenesis   [40]
6p21.31 ANKS1A rs17609940 0.75 1 x 10-8 1.07 (1.05-1.10) Immune system CAD [16]
6p21.33 HCG27, HLA-C rs3869109 NR 1 x 10-9 1.14 (NR) Unknown   [40]
6p24.1 PHACTR1 rs12526453
rs9349379
rs12526453
0.65
NR
0.67
1 x 10-9
9 x 10-26
1 x 10-9
1.12 (1.08-1.17)
NR
1.1 (1.06-1.13)
Coronary calcification MI
CAD
CAD
[39]
[43]
[16]
6q14.1 FAM46A - IBTK rs16893526 0.91 5 x 10-6 1.13 (1.07-1.21) Unknown CAD [44]
6q16.1 FHL5 rs12200560 NR 6 x 10-7 1.11 (NR) Transcriptional activation CAD [40]
6q23.2 TCSF21 rs12190287 0.62 1 x 10-12 1.08 (1.06-1.10) Tumor suppressor CAD [16]
6q25.1 MTHFD1L rs6922269 0.25 3 x 10-8 1.23 (1.15-1.33) Tetrahydrofolate synthesis CAD [32]
6q25.3 LPA rs3798220 0.02 3 x 10-11 1.51 (1.33-1.70) Lipoprotein (a) CAD [16]
6q25.3 FNDC1 rs365302 0.24 8 x 10-7 1.11 (1.06-1.15) Unknown CAD [44]
7q22.3 BCAP29 rs10953541 0.80 3 x 10-8 1.08 (1.05-1.11) Unknown   [43]
7q31.2 ASZ1 rs7808424 0.12 1 x 10-6 1.1 (1.06-1.14) Unknown CAD [16]
7q32.2 ZC3HC1 rs11556924 0.62 9 x 10-18 1.09 (1.07-1.12) Unknown CAD [16]
8q24.13 TRIB1 rs10808546 0.65   1.04 Lipids CAD [45]
9p21.3 ANRIL/CDKN2BAS CDKN2A, CDKN2B rs1333049
rs4977574
rs4977574
rs4977574
rs1333049
0.47
0.56
NR
0.46
0.49
3 x 10-19
3 x 10-44
2 x 10-25
1 x 10-22
7 x 10-58
1.36 (1.27-1.46)
1.29 (1.25-1.34)
1.20 (1.16-1.25)
1.29 (1.23-1.36)
1.27 (1.23-1.31)
Regulatory functions? CAD
MI
CAD
CAD
CAD
[32]
[39]
[43]
[16]
[44]
9q22.33 HEMGN – ANP32B rs4743150 NR 5 x 10-6 NR Unknown CAD [43]
9q34.2 ABO rs514659
rs579459
0.37
0.21
8 x 10-9
4 x 10-14
1.21 (1.13-1.28)
1.10 (1.07-1.13)
Coronary thrombosis CAD/MI
CAD
[17]
[16]
10p11.23 KIAA1462 rs3739998
rs2505083
0.44
0.38
1 x 10-11
4 x 10-8
1.15 (1.11-1.20)
1.07 (1.04-1.09)
Endothelial cell adhesion CAD
CAD
[42]
[43]
10q11.21 CXCL12 rs501120­
rs1746048
rs1746048
0.87
0.84
0.87
9 x 10-8
7 x 10-9
3 x 10-10
1.33 (1.20-1.48)
1.17 (1.11-1.24)
1.09 (1.07-1.13)
Platelet aggregation? CAD
MI
CAD
[32]
[39]
[16]
10q23.31 LIPA rs1412444
rs1412444
0.42
0.32
3 x 10-13
4 x 10-8
1.09 (1.07-1.12)
1.1 (1.07-1.14)
Lipids CAD [43]
[44]
10q24.32 CNNM2 rs12413409
rs12413409
NR
0.89
4 x 10-6
1 x 10-9
NR
1.12 (1.08-1.16)
Mg homeostasis? CAD
CAD
[43]
[16]
11q22.3 PDGFD rs974819 0.32 2 x 10-9 1.07 (1.04-1.09) Smooth muscle cell proliferation CAD [43]
11q23.3 ZNF259 rs964184 0.13 1 x 10-17 1.13 (1.10-1.16) Unknown CAD [16]
11q24.2 ST3GAL4 rs4937126 0.69 5 x 10-6 1.06 (1.04-1.09) Protein glycosylation CAD [16]
12q24.12 SH2B3 rs3184504 0.44 6 x 10-6 1.07 (1.04-1.10) Hematopoiesis CAD [16]
12q24.31 HFN1A rs2259816 0.36 5 x 10-7 1.08 (1.05-1.11) Transcription factor CAD [41]
13q34 COL4A1-A2 rs4773144 0.44 4 x 10-9 1.07 (1.05-1.09) Type IV collagen CAD [16]
14q32.2 HHIPL1 rs2895811 0.43 1 x 10-10 1.07 (1.05-1.10) Unknown CAD [16]
15q22.33 SMAD3 rs17228212 0.30 2 x 10-7 1.21 (1.13-1.30) Transcriptional modulator CAD [32]
15q25.1 ADAMTS7 rs1994016
rs43800028
rs3825807
0.60
0.65
0.57
5 x 10-13
4 x 10-9
1 x 10-12
1.19 (1.13-1.24)
1.07 (1.05-1.10)
1.08 (1.06-1.10)
Migration of vascular smooth muscle cells CAD
CAD
CAD
[17]
[43]
[16]
15q24.1 CYP1A1 – CYP1A2 rs2472299   3 x 10-6 NR Lipid synthesis? CAD [43]
17q12 ACCN1 rs11650066 NR 6 x 10-6 NR Sodium channel? CAD [43]
17p13.3 SMG6 rs216172 0.37 1 x 10-9 1.07 (1.05-1.09) Telomerase ribonucleoprotein complex CAD [16]
17p11.2 PEMT rs12936587 0.56 4 x 10-10 1.07 (1.05-1.09) Choline metabolism CAD [16]
17q21.32 UBE2Z rs46522 0.53 2 x 10-8 1.06 (1.04-1.08) Apoptosis? CAD [16]
17q23.3 PECAM1 rs6504218 NR 1 x 10-6 NR Angiogenesis? CAD [43]
19p13.2 LDLR rs1122608
rs1122608
0.75
0.77
2 x 10-9
1 x 10-9
1.15 (1.10-1.20)
1.14 (1.09-1.18)
LDL MI
CAD
[39]
[16]
19q13.2 APOE rs2075650 0.14   1.14 LDL CAD  
21q22.11 MRPS6, KCNE2 rs9982601
rs9982601
0.13
0.15
6 x 10-11
4 x 10-10
1.20 (1.14-1.27)
1.18 (1.12-1.24)
Voltage gated potassium channel MI
CAD
[39]
[16]
Xq23 CHRDL1 rs5943057 NR 9 x 10-7 NR Angiogenesis? CAD [43]
Table 2: Chromosome loci associated with coronary artery disease and myocardial infarction in populations of European descent.