Group |
Molecule |
Fuction |
Cell adhesion |
VCAM-1 |
Vascular cell adhesion molecule that mediates the adhesion of lymphocytes to vascular endothelium. |
ICAM-1 |
Intercellular adhesion molecule, expressed on endothelial cells, envolved in leukocyte endothelial transmigration. |
Molecules |
Selectin E |
Cell adhesion molecule expressed on endothelial cells activated by cytokines. Recruits leukocytes to the site of injury. |
Selectin P |
Cell adhesion molecule expressed on endothelial cells. Recruits leukocytes to the site of injury. |
Chemokines |
CCL3/MIP1α |
Inflammatory chemokine; acts in the recruitment and activation of leukocytes. |
CCL1/I-309 |
Inflammatory chemokine that attracts monocytes, NK cells, B cells and DCs. |
CXCL9/MIG |
Monokine induced by IFN-γ that attracts T cells. |
CCL17/TARC |
Expressed constitutively in thymus and transiently in activated PBMC; T cell chemoattractant. |
Chemokine |
CCR5 |
Plays a role inflammatory response to infections; expressed mainly on T cells, macrophages, DCs. Binds CCL1, 3 and 5. |
Receptors |
CCR8 |
Chemoattract activated T cells injury areas and lymphoidorgans. Binds CCL1. |