Group Molecule

Fuction

Cell adhesion VCAM-1 Vascular cell adhesion molecule that mediates the adhesion of lymphocytes to vascular endothelium.
ICAM-1 Intercellular adhesion molecule, expressed on endothelial cells, envolved in leukocyte endothelial transmigration.
Molecules Selectin E Cell adhesion molecule expressed on endothelial cells activated by cytokines. Recruits leukocytes to the site of injury.
Selectin P Cell adhesion molecule expressed on endothelial cells. Recruits leukocytes to the site of injury.
Chemokines CCL3/MIP1α Inflammatory chemokine; acts in the recruitment and activation of leukocytes.
CCL1/I-309 Inflammatory chemokine that attracts monocytes, NK cells, B cells and DCs.
CXCL9/MIG Monokine induced by IFN-γ that attracts T cells.
CCL17/TARC Expressed constitutively in thymus and transiently in activated PBMC; T cell chemoattractant.
Chemokine CCR5 Plays a role inflammatory response to infections; expressed mainly on T cells, macrophages, DCs. Binds CCL1, 3 and 5.
Receptors CCR8 Chemoattract activated T cells injury areas and lymphoidorgans. Binds CCL1.
Table 1: Molecules involved with T cells migration to the heart tissue.