Patient Site of oligoclonal T cell expansions TCR-Vbfamilies
SLA Periphery 7, 8, 23
Heart lesion - mitral valve 1, 2, 3, 5, 8, 9, 13, 14, 17
WFA Periphery Notdetected
Heart lesion - mitral valve 4, 5, 8, 14, 15, 17, 20
Heart lesion - aorticvalve 2, 5, 7, 13, 15
JSS Periphery 20
Heart lesion - mitral valve 1, 2, 3, 4, 5, 9, 11, 16, 17, 18, 20,21,23,24
Heart lesion - aorticvalve 1, 2, 13, 16, 18, 22, 23
Some expanded and oligoclonal T cell populations were found in both peripheral blood and the valves (bold), indicating that these expansions are antigen-driven thus auto reactive [23]
Table 2: Oligoclonal T cell expansions in peripheral blood and heart- tissueintralesional lineages.