Patient |
Site of oligoclonal T cell expansions |
TCR-Vbfamilies |
SLA |
Periphery |
7, 8, 23 |
Heart lesion - mitral valve |
1, 2, 3, 5, 8, 9, 13, 14, 17 |
WFA |
Periphery |
Notdetected |
Heart lesion - mitral valve |
4, 5, 8, 14, 15, 17, 20 |
Heart lesion - aorticvalve |
2, 5, 7, 13, 15 |
JSS |
Periphery |
20 |
Heart lesion - mitral valve |
1, 2, 3, 4, 5, 9, 11, 16, 17, 18, 20,21,23,24 |
Heart lesion - aorticvalve |
1, 2, 13, 16, 18, 22, 23 |
Some expanded and oligoclonal T cell populations were found in both peripheral blood and the valves (bold), indicating that these expansions are antigen-driven thus auto reactive [23] |