Parameter

Sham    

MI         

Sham + PRAZ    

MI + PRAZ         

Body wt (g)

685 ± 38

679 ± 27

696 ± 26

653 ± 46

Heart wt (mg)

1720 ± 55

2690 ± 79*

1900 ± 14

2300 ± 7#

Scar wt (mg)        

ND

763 ± 125

ND

670 ± 99

Scar wt/LV wt (%)

ND

41 ± 4

ND

39 ± 4    

Heart wt/body wt (mg/g)

2.71 ± 0.08

4.20 ± 0.13*

2.73 ± 0.20           

3.45 ± 0.18#         

RV wt (mg)          

386 ± 25

633 ± 75*

267 ± 21               

417 ± 31#

Lung wet/dry wt ratio

4.01 ± 0.06

5.23 ± 0.26*

4.26 ± 0.24

3.98 ± 0.25#

Liver wet/dry wt ratio

2.65 ± 0.11

2.91 ± 0.05

2.82 ± 0.03           

2.93 ± 0.17           

Values are a mean SE of 6 animals in each group. MI – Myocardial Infarction; PRAZ– Prazosin (10 mg/kg/day); ND – Not Detected; LV– Left Ventricle; RV – Right Ventricle;*P < 0.05 compared with the 20 week sham group; #P < 0.05 compared with the 20 week MI group
Table 1: General characteristics of sham and infarcted rats with and without prazosin treatment for 8 weeks starting at 12 weeks after coronary artery occlusion.