Parameter |
Sham |
MI |
Sham + PRAZ |
MI + PRAZ |
Body wt (g) |
685 ± 38 |
679 ± 27 |
696 ± 26 |
653 ± 46 |
Heart wt (mg) |
1720 ± 55 |
2690 ± 79* |
1900 ± 14 |
2300 ± 7# |
Scar wt (mg) |
ND |
763 ± 125 |
ND |
670 ± 99 |
Scar wt/LV wt (%) |
ND |
41 ± 4 |
ND |
39 ± 4 |
Heart wt/body wt (mg/g) |
2.71 ± 0.08 |
4.20 ± 0.13* |
2.73 ± 0.20 |
3.45 ± 0.18# |
RV wt (mg) |
386 ± 25 |
633 ± 75* |
267 ± 21 |
417 ± 31# |
Lung wet/dry wt ratio |
4.01 ± 0.06 |
5.23 ± 0.26* |
4.26 ± 0.24 |
3.98 ± 0.25# |
Liver wet/dry wt ratio |
2.65 ± 0.11 |
2.91 ± 0.05 |
2.82 ± 0.03 |
2.93 ± 0.17 |
Values are a mean SE of 6 animals in each group. MI – Myocardial Infarction; PRAZ– Prazosin (10 mg/kg/day); ND – Not Detected; LV– Left Ventricle; RV – Right
Ventricle;*P < 0.05 compared with the 20 week sham group; #P < 0.05 compared with the 20 week MI group |