| Parameter |
Sham |
MI |
Sham + PRAZ |
MI + PRAZ |
| A. Hemodynamic parameters |
|
|
|
|
| Heart rate (bpm) |
225 ± 5 |
234 ± 5 |
241 ± 6 |
238 ± 9 |
| LVSP (mm Hg) |
139 ± 4 |
74 ± 3* |
138 ± 3 |
102 ± 3# |
| LVEDP (mm Hg) |
5.1 ± 0.42 |
19.3 ± 0.61* |
5.2 ± 0.30 |
8.8 ± 0.33# |
| +dP/dt (mm Hg/s) |
7377 ± 390 |
3840 ± 139* |
6924 ± 331 |
4955 ± 166# |
| -dP/dt (mm Hg/s) |
5600 ± 150 |
2366 ± 235* |
5263 ± 104 |
3789 ± 311# |
| MAP (mm Hg) |
147 ± 15 |
131 ± 11 |
156 ± 13 |
142 ± 17 |
| B. Plasma catecholamines |
|
|
|
|
| Norepinephrine (pg/ml) |
182 ± 6.2 |
352 ± 11.5* |
163 ± 14.7 |
187 ± 17.3# |
| Epinephrine (pg/ml) |
80 ± 5.0 |
137 ± 6.3* |
80 ± 4.9 |
141 ± 13.1 |
| Dopamine (pg/ml) |
70 ± 8.2 |
202 ± 15.7* |
79 ± 6.2 |
174 ± 8.8 |
Values are mean ± SE of 6 animals in each group. LVSP–Left Ventricular Systolic Pressure; LVEDP–Left Ventricular End Diastolic Pressure; MI–Myocardial Infarction;
MAP–Mean Arterial Pressure; +dP/dt–rate of pressure development; -dP/dt rate of pressure decay; bpm–beats per min; PRAZ–Prazosin (10 mg/kg/day); *P <0.05 compared
with the 20 week sham group; #P <0.05 compared with the 20 week MI group |
