| Parameter |
Sham |
MI |
Sham + PRAZ |
MI + PRAZ |
| A. Parameters for interval dimensions |
|
|
|
|
| IVSd (cm) |
0.251 ± 0.03 |
0.219 ± 0.02 |
0.242 ± 0.01 |
0.271 ± 0.02 |
| IVSs (cm) |
0.394 ± 0.03 |
0.277 ± 0.03* |
0.355 ± 0.01 |
0.418 ± 0.02# |
| LVIDd (cm) |
0.861 ± 0.01 |
1.100 ± 0.04* |
0.875 ± 0.02 |
1.020 ± 0.06 |
| LVIDs (cm) |
0.477 ± 0.03 |
0.842 ± 0.03* |
0.537 ± 0.04 |
0.643 ± 0.04# |
| LVPWs (cm) |
0.257 ± 0.03 |
0.372 ± 0.02* |
0.246 ± 0.01 |
0.247 ± 0.01# |
| LVPWd (cm) |
0.350 ± 0.01 |
0.448 ± 0.03* |
0.309 ± 0.02 |
0.346 ± 0.02# |
| B. Cardiac performance parameters: |
|
|
|
|
| Ejection fraction (%) |
86 ± 3.0 |
44 ± 2.0* |
67 ± 4.0 |
64 ± 4.0# |
| Fractional shortening |
44 ± 3.9 |
21 ± 1.5* |
33 ± 3.5 |
32 ± 3.2# |
| (%)Cardiac output (L/min) |
0.479 ± 0.03 |
0.234 ± 0.03* |
0.433 ± 0.05 |
0.372 ± 0.03# |
| Heart rate (bpm) |
337 ± 8 |
369 ± 4 |
336 ± 15 |
348 ± 7 |
Values
are mean ± SE of 7 animals in each group. MI–Myocardial Infarction; PRAZ–Prazosin (10 Mg/Kg/Day); IVS–Internal Ventricular Septum; LVID–Left Ventricular
Internal Diameter; LVPW–Left Ventricular Posterior Wall; d–diastolic measurement; s–systolic measurement. *P<0.05 compared with the 20 week sham group. #P<0.05
compared with the 20 week MI group. |
