Gene Name Symbol Alias % neonatal PDA % neonatal mortality Reference
Prostaglandin-endoperoxide synthase 1 Ptgs1 Cyclooxygenase-1 0   [12]
Prostaglandin-endoperoxide synthase 2 Ptgs2 Cyclooxygenase-2 33 35 [12]
Prostaglandin-endoperoxide synthase 2 Ptgs2 Cyclooxygenase-2 57 57 [13]
Prostaglandin-endoperoxide synthase 2a Ptgs2   0 0 [13]
Ptgs2 (-/-) and Ptgs1 (+/-)     74 79 [12]
Ptgs2 (-/-) and Ptgs1 (-/-)     100 100 [12,14]
  Prostaglandin E synthase   Ptges Microsomal prostaglandin E
synthase-1
  0     [62]
Prostaglandin E receptor 4 Ptger4 PGE receptor EP4 >95 >95 [16-18]
Solute carrier organic anion transporter family, member
2A1
  Slco2a1   Prostaglandin transporter     100   [20]
Hydroxyprostaglandin dehydrogenase 15-(NAD) Hpgd Prostaglandin dehydrogenase >95 >95 [21, 22]
acyclooxygenase activity was inhibited without affecting peroxidase activity
Table 1: Summary of prostaglandin pathway mutant mouse models relevant to the ductus arteriosus.