Figure 29: Response to acetylcholine (ACh) and isosorbide dinitrate (ISDN) in patients > 10 years after acute Kawasaki syndrome. Aneurysms were present in Groups 1 (=4 mm) and 2 (< 4mm) during the acute illness but had completely resolved at the time of testing. Group 3 did not have aneurysms during the acute illness and Group 4 were controls with CHD but no history of Kawasaki disease. In both groups with healed aneurysms the endothelium-dependent response to acetylcholine is constriction indicating severe endothelial dysfunction. Also dilation in response to ISDN is less than in controls. Error bars = SEM. *p < 0.05 (ACh);**p < 0.05 (ISDN). (Modified from Iemura et al. [93] with permission).