| Cytokine name |
Effects |
References |
| IL-1 | Activation of osteoclasts Activation of Т-cells Activation of matrix metalloproteinases, destroying cartilage |
[7, 8] |
| TNF-α | Activation of osteoclasts, activation of matrix metalloproteinases Increase expression of HLA II molecules by antigen presenting cells Increase expression of intercellular adhesion molecules |
[9-11] |
| IL-6 | Activation of osteoclasts Support of B cells differentiation and antibody production |
[12] |
| IL-4 | Decrease of pro-inflammatory cytokines production Support of B cells differentiation and antibody production |
[13] |
| IL-10 | Decrease of pro-inflammatory cytokines synthesis Support of B cells differentiation and antibody production |
[12] |
| IFN-γ | Increase expression of HLA II molecules by antigen presenting cells Increase expression of intercellular adhesion molecules Enhancement of T-cell proliferation and Th1 cytokine production |
[14] |
| IL-18 | Increase of IFN-γ Т-cells production | [9-11] |
Table 1: Key effects of studied cytokines. |
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