Gene (SNP) | Genotype | RA cases, no (%) | Controls, no (%) |
IFN-γ (+874, rs2430561) | A/A A/T T/T |
20 (29%) 37 (54%) 12 (17%) |
40 (30%) 64 (48%) 29 (22%) |
IL-1α (-899, rs1800587) | C/C T/C T/T |
36 (52%) 27 (39%) 6 (9%) |
68 (51%) 53 (40%) 12 (9%) |
IL-1α (+4845, rs17561) | G/G G/T T/T |
29 (42%) 32 (46%) 8 (11%) |
66 (50%) 55 (41%) 12 (9%) |
IL-1β (-31, rs1143627) | T/T T/C C/C |
22 (32%) 43 (62%) 4 (6%) |
48 (36%) 71 (53%) 14 (11%) |
IL-1β (-511, rs16944) | C/C T/C T/T |
17 (25%) 44 (63%) 8 (12%) |
49 (37%) 70 (53%) 14 (10%) |
IL-1β (+3953, rs1143634) | C/C T/C T/T |
38 (55%) 28 (41%) 3 (4%) |
84 (63%) 39 (29%) 10 (8%) |
IL-4 (-590, rs2243250) | C/C C/T T/T |
20 (29%) 45 (65%) 4 (6%) |
81 (61%) 48 (36%) 4 (3%) |
IL-6 (-174, rs1800795) | G/G G/C C/C |
31 (45%) 29 (42%) 9 (13%) |
37 (28%) 68 (51%) 28 (21%) |
IL-10 (-592, rs1800872) | C/C C/A A/A |
28 (41%) 33 (48%) 8 (12%) |
84 (63%) 44 (33%) 5 (4%) |
IL-10 (-819, rs1800871) | C/C C/T T/T |
37 (54%) 24 (35%) 8 (11%) |
85 (64%) 43 (32%) 5 (4%) |
IL-10 (-1082, rs1800896) | G/G G/A A/A |
12 (17%) 49 (71%) 8 (12%) |
28 (21%) 70 (53%) 35 (26%) |
IL-18 (-137, rs187238) | G/G G/C C/C |
26 (38%) 43 (62%) 0 |
70 (53%) 52 (39%) 11 (8%) |
IL-18 (-607, rs1946518) | C/C C/A A/A |
28 (42%) 29 (41%) 12 (17%) |
45 (34%) 64 (48%) 24 (18%) |
TNFα (-238, rs361525) | G/G G/A A/A |
63 (91%) 6 (9%) 0 |
129 (97%) 4 (3%) 0 |
TNFα (-308, rs1800629) | G/G G/A A/A |
37 (54%) 32 (46%) 0 |
99 (74%) 34 (26%) 0 |
Table 2: Distribution of genotypes among patients with RA and healthy control group. |