| Gene | SNP | Pvalue | Allele associated with susceptibilit y (Allele Frequency) |
Genotype associated with susceptibility |
Odds Ratio (OR) (95% CI) |
Relative Risk (RR) |
Effect: × risk for RA |
| IFN-γ | A/T (rs2430561) |
>0.05 | – | – | – | – | – |
| IL-1α | C/T (rs1800587) |
>0.05 | – | – | – | – | – |
| G/T (rs17561) |
>0.05 | – | – | – | – | – | |
| IL-1β | C/T (rs1143627) |
>0.05 | – | – | – | – | – |
| C/T (rs16944) |
>0.05 | – | – | – | – | – | |
| C/T (rs1143634) |
>0.05 | – | – | – | – | – | |
| IL-4 | C/T (rs2243250) |
0.0001 | T (0.164) | T/T C/T |
1.98 (0.4808 to 8.1912) 3.32 (1.8062 to 6.1036) |
1.93 1.81 |
×2.0 ×3.2 |
| IL-6 | G/C (rs1800795) |
0.0147 | G (0.479) | G/G | 2.12 (1.1531 to 3.8852) |
1.62 | ×2.1 |
| IL-10 | C/A (rs1800872) |
0.0022 | A (0.239) | A/A C/A |
3.36 (1.0544 to 10.6909) 1.85 (1.0231 to 3.3605) |
3.08 1.45 |
×3.4 ×1.9 |
| C/T (rs1800871) |
>0.05 | – | – | – | – | – | |
| G/A (rs1800896) |
0.0118 | G (0.533) | G/G G/A |
2.72 (1.1851 to 6.2574) 2.21 (1.1843 to 4.1053) |
1.35 1.19 |
×2.7 ×2.2 |
|
| IL-18 | G/C (rs187238) |
0.0017 | C (0.292) | G/C | 2.58 (1.4157 to 4.6878) |
1.59 | ×2.6 |
| C/A (rs1946518) |
>0.05 | – | – | – | – | – | |
| TNFα | G/A (rs361525) |
>0.05 | – | – | – | – | – |
| G/A (rs1800629) |
0.0028 | A (0.217) | G/A | 2.52 (1.3643 to 4.6483) |
1.81 | ×2.5 | |
Table 3: Association between rheumatoid arthritis and investigated SNPs. |
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