Gene SNP Pvalue Allele
associated
with
susceptibilit
y (Allele
Frequency)
Genotype
associated
with
susceptibility
Odds Ratio (OR)
(95% CI)
Relative
Risk
(RR)
Effect:
× risk for
RA
IFN-γ A/T
(rs2430561)
>0.05
IL-1α C/T
(rs1800587)
>0.05
G/T
(rs17561)
>0.05
IL-1β C/T
(rs1143627)
>0.05
C/T
(rs16944)
>0.05
C/T
(rs1143634)
>0.05
IL-4 C/T
(rs2243250)
0.0001 T (0.164) T/T
C/T
1.98
(0.4808 to 8.1912)
3.32
(1.8062 to 6.1036)
1.93
1.81
×2.0
×3.2
IL-6 G/C
(rs1800795)
0.0147 G (0.479) G/G 2.12
(1.1531 to 3.8852)
1.62 ×2.1
IL-10 C/A
(rs1800872)
0.0022 A (0.239) A/A
C/A
3.36
(1.0544 to 10.6909)
1.85
(1.0231 to 3.3605)
3.08
1.45
×3.4
×1.9
C/T
(rs1800871)
>0.05
G/A
(rs1800896)
0.0118 G (0.533) G/G
G/A
2.72
(1.1851 to 6.2574)
2.21
(1.1843 to 4.1053)
1.35
1.19
×2.7
×2.2
IL-18 G/C
(rs187238)
0.0017 C (0.292) G/C 2.58
(1.4157 to 4.6878)
1.59 ×2.6
C/A
(rs1946518)
>0.05
TNFα G/A
(rs361525)
>0.05
G/A
(rs1800629)
0.0028 A (0.217) G/A 2.52
(1.3643 to 4.6483)
1.81 ×2.5
Table 3: Association between rheumatoid arthritis and investigated SNPs.