Gene Genotype RA patients,
no. (%)		 Controls,
no. (%)		 Alleles associated
with susceptibility
(P-value)
-590 (IL-4) and
-137 (IL-18)		 СС GG
ТТ GG
СТ GG
СС GC
ТТ GC
СТ GC
СС CC
ТТ CC
СТ CC		 9 (13%)
3 (4%)
14 (20%)
11 (16%)
1 (1%)
31 (45%)
000		 46 (35%)
1 (1%)
23 (17%)
31 (23%)
3 (2%)
18 (14%)
4 (3%)
0
7 (5%)		 590T and 137C
(0.01955)
-819 (IL-10) and
-592 (IL-10)		 CC CC
ТТ CA
CT CA
CC CA
CC AA
TT CC
TT AA
CT AA
CT CC		 28 (41%)
0
24 (35%)
9 (13%)
00
8 (11%)
00		 84 (63%)
0
43 (32%)
1 (1%)
00
5 (4%)
00		 819C and 592A
(0.00754)
-238 (TNFα) and
-590 (IL-4)		 GG CC
GA CC
GG CT
GA CT
GG TT
GA TT		 17 (25%)
3 (4%)
42 (61%)
3 (4%)
4 (6%)
0		 79 (59%)
2 (1%)
46 (34%)
2 (1%)
4 (3%)
0		 238A and 590T
(0.0311)
-308 (TNFα) and
-590 (IL-4)		 GG CC
GA CC
GG CT
GA CT
GG TT
GA TT		 12 (17%)
8 (12%)
23 (33%)
22 (32%)
2 (3%)
2 (3%)		 61 (45%)
20 (15%)
36 (27%)
12 (9%)
2 (2%)
2 (2%)		 308A and 590T
(0.0361)
-308 (TNFα) and
-592 (IL-10)		 GG CC
GA CC
GG CA
GA CA
GA CA
GA AA		 19 (27%)
9 (13%)
14 (20%)
19 (27%)
4 (6%)
4 (6%)		 56 (42%)
28 (21%)
38 (29%)
6 (4%)
5 (4%)
0		 308A and 592A
(0.00471)
-308 (TNFα) and
-137 (IL-18)		 GG GC
GA GC
GG GG
GA GG
GG CC
GA CC		 20 (29%)
23 (33%)
17 (25%)
9 (13%)
00		 42 (32%)
10 (7%)
51 (38%)
19 (14%)
6 (5%)
5 (4%)		 308A and 137C
(0.0294)
Table 4: Presence of combined genotypes among patients with RA and healthy individuals and their significant association with RA (p<0.05).