TLR type |
Function |
TLR 1+ TLR 6 |
Recognises triacyl peptides [11]. Decreases infection related morbidity and mortality. Necessary for good vaccine response [92]. |
TLR2 in complex with TLR1 or TLR6 |
Lipoproteins and lipopeptides recognition [12,25] |
TLR3 |
Viral double-stranded RNA recognition and trigger apoptosis directly [13]. |
TLR4 |
Lipopolysaccharide recognition [15]
Germinal centre formation, Ig maturation [93], Neuroinflammation and brain damage [94]. |
TLR5 |
Flagellin recognition [30]
Protect the intestine from commensal bacteria [95] |
TLR7 or TLR8 |
Single-stranded RNA recognition [17]
Chemoresistance [96]. |
TLR9 |
Microbial DNA recognition [18] |
TLR 10 |
Only human TLR without any agonist or function [97]. |
TLR 11 |
Preventing infection to internal organs of urinogenital system [20]. |
TLR 12 |
Unknown [21] |
TLR 13 |
Unknown [21] |