Figure 6: A Smac mimetic overcomes the inhibitory effects of Bcl-2D/A and Bcl-xLD/A. (A) Cells were treated with 3 μM of the Smac mimetic and 10 nM of CID as indicated. Percentages of cell death (Mean ± standard deviations from triplicate wells) are displayed from a representative experiment. (B) Cells were treated as in (A) and caspase-3-like activity (Mean ± standard deviations from triplicate wells) was measured in a luminescence-based assay (Caspase-Glo 3/7, Promega). RLU: Relative Light Units.