Figure 3: Cyclosporine A significantly inhibited DSS induced weight loss and histopathology. Mice were given either drinking water or 3% DSS in the drinking water for 5 days followed by drinking water alone for the remainder of the study. Vehicle or Cyclosporine A was orally dosed BID at 15mg/kg daily and mouse body weight was measured daily. a) Daily percentage body weight change. b) Serum haptoglobin was assayed by ELISA on samples of individual mouse. Results reported as group means + SEM. c) Representative images of H&E stained colon sections.