Figure 4: Compound A significantly inhibited DSS induced weight loss, reduced serum haptoglobin level and improved histopathology. Mice were administered either drinking water or 3% DSS in the drinking water for 5 days followed by drinking water alone for the remainder of the study. Vehicle or Compound A was orally dosed BID at 40 mg/kg daily and mouse body weight was measured daily. a) Daily percentage body weight change. b) Serum haptoglobin level as measure by ELISA. c) H&E colon sections.