BMI ≤ 30 kg/m2 OR IC (95%) p BMI ≤ 25 kg/m2 OR IC (95%) p
  Genotype Patients n= 73 Controls n=99     Patients n=57 Controls n=90    
Co-dominant model n (%) n (%)     n (%) n (%)    
GG 17 (23.3) 25 (25.3)     20 (35.1) 23 (25.6)    
GA 42 (57.5) 48 (48.5) 1.28 (0.61-2.70) 0.50 29 (50.9) 47 (52.2) 0.70 (0.33-1.51) 0.37
AA 14 (19.2) 26 (26.2) 0.79 (0.32-1.93) 0.60 8 (14.0) 20 (22.2) 0.40 (0.16-1.27) 0.13
Dominant model                
GG* 17 25     20 23    
GA + AA 56 74 1.11 (0.54-2.25) 0.76 37 67 0.63 (0.30-1.13) 0.21
Recessive model                
GG* + GA 59 73     49 70    
AA 14 26 0.66 (0.32-1.38) 0.2 8 20 0.57 (0.23-1.40) 0.21
Allele                
G 76 (52.1) 98 (49.5)            
A 70 (49.4) 100 (50.5)   0.63 69 (60.5) 93 (51.7)    
          45 (39.5) 87 (48.3)   0.13
OR: Odds Ratio; CI: Confidence Interval.
Categorical variables were compared using the χ2 test
Table 2: Genotype distribution and allele frequencies of the G-2548A LEP polymorphism in breast cancer patients and control women, stratified into obese (BMI ≥ 30 kg/ m2) and normal-weight (BMI ≤ 25 kg/m2) groups.