Direct Indirect PKR (Protein Kinase-R) Up-regulation of human leukocyte antigen (HLA) class 1 expression. Which leads to Enhancing terminal differentiation of DCs 2’-5’ oligoadenylatesynthetase (2’-5’ OAS/ Rnase system) T-Cell antiproliferative effects Mx Protein Stimulation of IFN-γ by CD-4 T cells   Up regulation of the expression of HCV antigens (modification of immunoproteosomes) required for presentation of antigens

Table 1: The direct and indirect mechanisms followed by interferons to counter viral attack and enhance host immunity.