Direct Indirect
PKR (Protein Kinase-R) Up-regulation of human leukocyte antigen (HLA) class 1 expression.
Which leads to
Enhancing terminal differentiation of DCs
2’-5’ oligoadenylatesynthetase
(2’-5’ OAS/ Rnase system)
T-Cell antiproliferative effects
Mx Protein Stimulation of IFN-γ by CD-4 T cells
  Up regulation of the expression of HCV antigens (modification of immunoproteosomes) required for presentation of antigens
Table 1: The direct and indirect mechanisms followed by interferons to counter viral attack and enhance host immunity.