Figure 2: Immunoproteasome as part of the early antiviral response in pancreatic β-cells.
(A). β-cell infected with a virus (red) would secrete type I interferons α and β (IFNα/β) as part of early antiviral response (green).
(B). Neighboring uninfected β-cells would also undergo early antiviral response (green) as a result of exposure to type I IFNs secreted by the virus-infected β-cell. In each case, induced expression of the immunoproteasome would promote antigen processing for presentation by MHC class I molecules (blue). Antigens derived from β-cell proteins could stimulate the onset of autoimmunity. See text for details.