The induction of EAE in rats and treatment with Metf and/or LOV or vehicle were as detailed in Figure 1 legend. Shown are the composite mean ± SEM of three to four samples/group analyzed in triplicate to determine the levels of IFN-γ (A), IL-4 (B), ROR-γt (C) and IL-10 (D) mRNA transcripts in the SCs of EAE rats on peak clinical day. Shown are the composite mean ± SEM of three to four samples/group analyzed in triplicate to determine the levels of IFN-γ (A), IL-17A (B) protein in the SCs of EAE rats on peak clinical day. Differences were statistical significance as described for Figure 1 legend.
