Figure 4: Metf and LOV combination limits the expression of proinflammatory cytokines and T cells markers in the SCs of EAE rats.
The induction of EAE in rats and treatment with Metf and/or LOV or vehicle were as detailed in Figure 1 legend. Shown are the composite mean ± SEM of three to four samples/group analyzed in triplicate to determine the levels of TNF-α (A), IL-23 (B), CD4 (C) and CD8 (D) mRNA transcripts in the SCs of EAE rats on peak clinical day. Differences were statistical significance as described for Figure 1 legend.