Figure 4: Metabolites altered in EAE compared to healthy group map to multiple biosynthetic pathways. A. Each of 80 KEGG pathways plotted according to Global Test p-value (vertical axis, intensity of color) and impact factor (horizontal axis, size of circle). B. Statistics for pathways with major change based on the p value (pathways 1-4) or on high impact (pathways 5-6).