Number BIOCHEMICAL SUPER_PATHWAY SUB_PATHWAY PLATFORM KEGG T-stat pvalue qvalue
1 alpha-muricholate Lipid Bile acid metabolism LC/MS Neg C17647 -3.020 0.0181 0.1388
2 tetradecanedioate Lipid Fatty acid, dicarboxylate LC/MS Neg   -4.012 0.0018 0.0290
3 deoxycholate Lipid Bile acid metabolism LC/MS Neg C04483 -4.695 0.0010 0.0268
4 taurodeoxycholate Lipid Bile acid metabolism LC/MS Neg C05463 -5.059 0.0008 0.0268
5 glycolate (hydroxyacetate) Xenobiotics Chemical GC/MS C00160 -3.553 0.0080 0.1026
6 citrulline Amino acid Urea cycle; arginine-, proline-, metabolism LC/MS Pos C00327 -4.007 0.0017 0.0290
7 kynurenate Amino acid Tryptophan metabolism LC/MS Neg C01717 -2.400 0.0410 0.2095
8 3-(4-hydroxyphenyl)lactate Amino acid Phenylalanine & tyrosine metabolism LC/MS Neg C03672 -2.717 0.0188 0.1388
9 1,5-anhydroglucitol (1,5-AG) Carbohydrate Glycolysis, gluconeogenesis, pyruvate metabolism GC/MS C07326 -5.327 0.0013 0.0268
10 3-phosphoglycerate Carbohydrate Glycolysis, gluconeogenesis, pyruvate metabolism GC/MS C00597 -2.869 0.0141 0.1322
11 alpha-ketoglutarate Energy Krebs cycle GC/MS C00026 -2.289 0.0460 0.2109
12 anserine Peptide Dipeptide derivative LC/MS Neg C01262 -2.208 0.0511 0.2235
Table 2: Down-regulated metabolites in plasma of EAE compared to healthy group.