Clinical Feature Score
Female gender +2
ALP:AST ratio  
<1.5 +2
1.5-3.0 0
>3.0 -2
Serum globulin or IgG above normal  
>2.0 +3
1.5-2.0 +2
1.0-1.5 +1
<1.0 0
ANA, SMA, or LKM-1  
>1:80 +3
1:80 +2
1:40 +1
<1:40 0
AMA  
positive -4
Hepatitis viral markers  
Positive -3
Negative +3
Drug history  
Positive -4
Negative +1
Average alcohol intake  
<25 g/day +2
>60 g/day -2
Liver histology  
Interface hepatitis +3
Predominante lymphoplasmacytic infiltrate +1
Rosetting of liver cells +1
None of the above -5
Biliary changes -3
Other changes -3
Other autoimmune disease +2
Optional additional parameters  
Seropositivity for other defined autoantibodies +2
HLA DR3 or DR4 +3
Response to therapy  
Complete +2
Relapse +3
Interpretation of aggregate scores:  
Pre-treatment  
Definite AIH >15
Probable AIH 10-15
Post-treatment  
Definite AIH >17
Probable AIH 12-17
ALP: Alkaline Phosphatase; AST: Aspartate Transaminase; IgG: Immunoglobulin G; ANA: Anti-nuclear Antibodies; SMA: Smooth Muscle Antibodies; LKM-1: Type 1 Liver-kidney Microsomal antibodies; AMA: Anti-Mitochondrial Antibodies; HLA: Human Leucocyte Antigen
Table 2: Revised IAHG Scoring System for the diagnosis of AIH.