Figure 1: (A) Effect of melatonin on kainic acid induced iNOS mRNA expression on splenic lymphocytes and enriched T lymphocytes from mouse spleen using real time PCR. (a) Normal control, (b) Kainic acid control (1 mM), (c) Melatonin (1 mM), (d) Kainic acid (1 mM)+Melatonin (0.25 mM), (e) Kainic acid (1 mM)+Melatonin (0.5 mM), (f) Kainic acid (1 mM)+Melatonin (1 mM). Values are mean ± S.D; *P<0.005 (compared to respective normal control); $P<0.005 (compared to Kainic acid control). n=3 in each group. (B) Effect of melatonin on kainic acid induced alterations on MAPK 14 gene mRNA expression of splenic lymphocytes and enriched T lymphocytes from mouse spleen using real time PCR. (a) Normal control, (b) Kainic acid control (1 mM), (c) Melatonin (1 mM), (d) Kainic acid (1 mM)+Melatonin (0.25 mM), (e) Kainic acid (1 mM)+Melatonin (0.5 mM), (f) Kainic acid (1 mM)+Melatonin (1 mM). Values are mean ± S.D; *P<0.005 (compared to respective normal control); #P<0.05(compared to Kainic acid control) and $P<0.005 (compared to Kainic acid control). n=3 in each group.