Test in differentiating UC&healthy
Sensitivity
Specificity
Accuracy
PPV at pretest probability=
NPV at pretest probability=10%
50%
90%
s.HLA-G
47.4
100.0
66.1
100.0
100.0
94.5
Anti-Elastase
63.2
100.0
76.3
100.0
100.0
96.1
Anti-lysozyme
55.3
100.0
71.2
100.0
100.0
95.3
Anti-Cathep.-G
5.3
90.5
35.6
35.6
83.3
89.6
Test in differentiating CD and Healthy
s.HLA-G
100.0
100.0
100.0
100.0
100.0
100.0
Anti-Elastase
100.0
100.0
100.0
100.0
100.0
100.0
Anti-lysozyme
25.0
100.0
67.6
100.0
100.0
92.3
Anti-Cathepsin-G
43.8
90.5
70.3
82.1
97.6
93.5
Table 6:
Validity parameters for selected serum antibodies when used as test to diagnose UC and CD differentiating them to healthy controls.