Figure 4: Receiver operating characteristic curve (ROC) of uMCP-1 compared with standard parameters for LN activity. A. uMCP-1 compared with urinary parameters and SLEDAI-2K (renal). B) uMCP-1 compared with blood parameters and eGFR. The black solid curve in Figure A and B represents the uMCP-1; the area under the curve (AUC) was 0.82 (p=0.001). The AUC for proteinuria was 0.94 (p<0.001) and those for haematuria and leucocyturia were 0.72 (p=0.001) and 0.65 (p=0.23) respectively. The AUC for SLEDAI-2K was 0.96 (p<0.001). The AUC for serum albumin was 0.24 (p=0.001) and that for serum creatinine was 0.58 (p=0.21). The AUC for eGFR was 0.41 (p=0.21). Thus, uMCP-1 was better than haematuria, leucocyturia serum albumin, serum creatinine and eGFR but was not as good as proteinuria (uPCI) and SLEDAI-2K renal score for detection of LN activity.