Parameters Active LN n=47 Inactive LN n=53 p value
Haemoglobin (NR14.0-17.0 g/dL) 12.2 (8.6-16.6) 12.3 (8.5-15.6) 0.57
Total WBC (NR 4.0-10.0 × 109/L) 7.7 ± 3.6 7.1 ± 2.65 0.45
Platelet count (NR 150-400) 234 ± 112 256 ± 83.5 0.19
Serum albumin (NR 35-50 g/L) 37.78 ± 5.54 41.88 ± 3.59 <0.001
Serum creatinine (NR 44-80 μmol/L) 69 (33-252) 63 (41-158) 0.29
eGFR (ml/min/1.73 m2) 93.61 ± 46.01 99.75 ± 31.54 0.43
uPCI (NR<200 mg/mmol) 1100 (100-5100) 200 (100-500) <0.001
uMCP-1 ( (pg/mg creatinine) 9317.5 (548.3-40170) 3682 (0-23.86) <0.001
Serum C3 (NR 79-152 mg/dL) 100.5 ± 36.39 109.62 ± 39.94 0.24
Serum C4 (NR 16-38 mg/dL) 21.46 ±12.82 22.94 ± 11 0.54
Anti dsDNA Ab titres (NR<30 IU) 35.18 (1.73-195.97) 24.24 (0.81- 279.21) 0.84
SLEDAI-2K (global: 0-105) 8 (0-18) 2 (0-10) <0.001
SLEDAI-2K (renal: 0-16) 4 (0-16) 0 (0-3.5) <0.001
SLEDAI-2K (extra-renal: 0-89) 2 (0-10) 2 (0-10)  0.66
Medications, no. (%)      
- Prednisolone 43 (91.5) 52 (98.1) 0.12
- Cyclophosphamide 8 (17) 0 (0) 0.002
- Mychophenolic acid 12 (25.5) 10 (18.9) 0.42
- Cyclosporine/Tacrolimus 19 (40.4) 11 (20.8) 0.03
- Azathioprine 12 (25.5) 24 (45.3) 0.04
- Hydroxychloroquine 20 (42.6) 22 (41.5) 0.91
- Renin Angiotension System Blockers (ACEI/ARB/Spironolactone) 29 (61.7) 39 (73.6) 0.11
Values are in median (interquartile range) or mean (standard deviation). [p values were calculated by Mann-Whitney U test or Independent sample T test]; LN: Lupus Nephritis; WBC: White Blood Cell count; eGFR: Estimated Glomerular Filtration Rate; uPCI: Urine Protein Creatinine Index; SLEDAI-2K: Systemic Lupus Erythematosus Disease Activity Index-2K; anti-dsDNA: Anti Double Stranded DNA; C3: Complement 3; C4: Complement 4.
Table 2: Comparison between patients with and without active LN.