Figure 3: Versatility of monocytes pro-inflammatory activation switching in FMF patients. IL-10 production by monocytes isolated from ND and FMF patients after stimulation by pro- and antiinflammatory agents and after stimulation arrest or a further counter stimulation (A, B and C). Monocytes were unstimulated or stimulated by recombinant IL-4 or LPS for 3 days and on day 3, cells washed and fresh medium added or stimulated with opposite pro- or anti-inflammatory molecules for additional 3 days. The IL-10 production by monocytes was assayed by ELISA. All data represent means ± SEM (error bars) and are significantly different comparing FMF with ND (* Pt<0.05).