| Patient # |
GI manifestation prior to or at diagnosis |
GI manifestation during follow up |
Specific GI therapy (length of therapy) |
| 1 |
Constipation, colitis |
None |
Hypoallergenic diet |
| 2 |
None |
Oral aphthous ulcers, vomiting and diarrhea |
None |
| 3 |
Colitis |
Recurrent colitis, tongue ulcers, intussusceptions. |
Mesalamine. |
| 4 |
Prolonged diarrhea, chronic constipation |
Oral aphthous ulcers |
None |
| 5 |
Colitis |
Oral aphthous ulcers, colitis relapse, peri-anal abscess |
Systemic steroids |
| 6 |
NA* |
Colitis, peri-anal fissure, lower GI bleeding, inflammatory colonic polyps |
Systemic steroids (1.2 years), Mesalamine, Azathioprine. |
| 7 |
NA* |
Peri-anal fissure, colitis, constipation |
Peri-anal fissure Surgery, stool softeners |
| 8 |
None |
Oral aphthous ulcers |
None |
| 9 |
Vomiting, colitis |
Spontaneous small bowel perforation, colonic strictures |
Systemic steroids (11.6 years), Mesalamine, Azathioprine, Metronidazole, Gastric feeding tube, Home total parenteral nutrition. |
| 10 |
Colitis |
None |
Systemic steroids (4 years), Metronidazole |
| 11 |
Peri-anal disease |
Colitis, lower GI bleeding, recurrent peri-anal fissures |
Systemic steroids (0.25 years), Colectomy |
| *NA: Not applicable as diagnosed at birth due to family history of CGD; FTT: Failure To Thrive; GI: Gastrointestinal; INFg: Interferon-gamma |
