| Compound |
Isoform-Specificity |
Protein/enzyme/gene |
Cellular response |
Disease |
Reference |
| MS-275 |
HDACs 1,2,3,9 |
↑Foxp3
↓nuclear NFκB p65, VEGF |
↑IL-10
↓IL-1β, IFN-γ, IL-17, IL-18, TNF-α, IL-18, NO |
RA |
[64,122] |
| MI192 |
HDAC3 |
ND |
↓TNF, IL-6, IFN-γ |
RA |
[87] |
| MGCD0103 |
HDACs 1,2,3,11 |
Jak/STAT
↑NF-κB activation, TNFSF4, TNFSF9, TNF
↓TNFRSF8 |
↑TNF-α |
ND |
[79,80] |
| Valproic acid |
HDACs 1,2,3,8 |
PI3K/Akt, mTOR, NF-κB |
↓TNF-α |
ALPS, SLE, IBD |
[52,78] |
| FK228 |
HDACs 1,2,3,4 |
ND |
↓IL-1β, TNF-α |
AMA, RA, diabetes |
[20,88,89] |
| ACY-738 |
HDAC6 |
Foxp3 |
↑TGF-β
↓IL-1β |
SLE |
[117]
Unpublished data |
| Tubacin |
HDAC6 |
α-tubulin, HSp90 Foxp3
↑CTLA-4, PD-1, GITR |
↓IL-2, IFN-γ
↑IL-10 |
RA, IBD |
[109,123] |
| Tubastatin A |
HDAC6 |
α-tubulin, Foxp3 |
↓TNF-α, IL-6 |
RA, IBD |
[114,124] |
| ND: No data |
|
