Serological Marker Severity of Crohn's Disease References
anti-GM-CSF Stricturing Ileal Disease
Generalized Stricturing and penetrating disease
Dykes et al. [63]
Gathungu et al. [65]
ASCA-IgG Stricturing and penetrating disease
Risk of Surgery
Ileal involvement
Dassopoulos et al. [67]
Eser et al. [72]
anti- flagellin Small bowel disease
Penetrating and fibrostenosing disease
Targan et al. [71]
Pancreatic autoantibodies Penetrating disease
Perianal disease
Extrainstinal manifestations
Lakatos et al. [76]
anti-GP2 Stricturing and perianal disease Bogdanos et al. [77]
GM-CSF: Granulocyte-Macrophage Colony-Stimulating Factor; ASCA-IgG: Anti-Saccharomyces cerevisae Antibody Immunoglobulin G; GP2: Glycoprotein 2
Table 2: Serological Markers of Severity in Crohn’s Disease. Key markers involved in adaptive mucosal immune response in Crohn’s disease.