Serological Marker |
Severity of Crohn's Disease |
References |
anti-GM-CSF |
Stricturing Ileal Disease
Generalized Stricturing and penetrating disease |
Dykes et al. [63]
Gathungu et al. [65] |
ASCA-IgG |
Stricturing and penetrating disease
Risk of Surgery
Ileal involvement |
Dassopoulos et al. [67]
Eser et al. [72] |
anti- flagellin |
Small bowel disease
Penetrating and fibrostenosing disease |
Targan et al. [71] |
Pancreatic autoantibodies |
Penetrating disease
Perianal disease
Extrainstinal manifestations |
Lakatos et al. [76] |
anti-GP2 |
Stricturing and perianal disease |
Bogdanos et al. [77] |
GM-CSF: Granulocyte-Macrophage Colony-Stimulating Factor; ASCA-IgG: Anti-Saccharomyces cerevisae Antibody Immunoglobulin G; GP2: Glycoprotein 2