Figure 2: An adult human ovary with dormant primordial follicles before and after exposure to cyclophosphamide. The number of quiescent primordial follicles determines ovarian reserve. Solid arrows in the figure A show healthy primordial follicles whereas dashed arrows in the figure B point apoptotic death of the oocytes and surrounding granulosa cells after exposure to cyclophosphamide. Scale bars 100 microns.