Figure 5: MMP imaging in neuroinflammation (A) Combined FMT and MR imaging of brain tumors with Prosense demonstrates focal activity of protease activity associated with gliomas. Prosense signal correlated well with tumor size on MRI. (B) In vivo fluorescence imaging at 24 hours after MCAO in mice, where strong fluorescence was detected over the infarcted hemisphere. In contradistinction, very little signal increase was seen with MMPsense in sham mice or with control probe in stroke mice [70]. (C) Ex vivo correlation of Prosense signal (Cy5.5 channel) with TTC staining, and with BBB breakdown (FITC-albumin) in stroke mice. (Modified from McCann et al. [72] and Klohs et al. [70] with permission.).