Gene Full name Fold change P-value Methylation Chromosome Function
NINJ2 Ninjurin (for nerve injury induced) -6.01644 0.025353 hypomethylation 12 Neuron adhesion
TXNRD1 Thioredoxinreductase 1 -3.55680 0.000165 hypomethylation 12 Ribonucleotide binding, nucleotide binding, oxidation reduction
BRWD1 Bromodomain and WD repeat domain containing 1 -3.31289 0.000813 hypomethylation 21  
ATP9B ATPase, class II, type 9B -3.26934 0.014517 hypomethylation 18 Nucleotide biosynthetic process, purine biosynthetic process
ASXL2 Additionalsex combs like 2 (Drosophila) -3.11677 0.028253 hypomethylation 2  
HSPE1 Heatshock 10kDa protein 1 -3.07642 0.002192 hypomethylation 2 Purine nucleotide binding, Ribonucleotide binding, nucleotide binding,
HSPD1 Heatshock 60kDa protein 1 (chaperonin) -3.03374 0.002294 hypomethylation 2 Purine nucleotide binding, Ribonucleotide binding, nucleotide binding
KDM2B Lysine(K)-specific demethylase 2B -3.01638 0.002514 hypomethylation 12 Oxidation reduction,
COG3 Component of oligomeric golgi complex 3 -2.96826 0.025353 hypomethylation 13 Protein localization in organelle, intra-Golgi vesicle-mediated transport, cellular macromolecule localization, cellular protein localization, retrograde vesicle-mediated transport, Golgi to ER, Golgi transport complex, protein transporter activity
NR3C1 Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -2.66399 0.008423 hypomethylation 5 Intracellular signalling cascade,
ADAMTSL1 ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) -2.65750 0.005077 hypomethylation 9  
SELT Selenoprotein T -2.57892 0.002665 hypomethylation 3  
MX1 Myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) -2.53843 0.045739 hypomethylation 21 Purine ribonucleotide binding,
MACF1 Microtubule-actin crosslinking factor 1 -2.53607 0.001098 hypomethylation 1 Protein localization in organelle, cellular macromolecule localization, cellular protein localization, microtubule cytoskeleton,
FRMD4A FERM domain containing 4Ap -2.47480 0.003371 hypomethylation 10  
DMXL1 Dmx-like 1 -2.43990 0.029074 hypomethylation 5  
PGD Phosphogluconate dehydrogenase -2.43270 0.003595 hypomethylation 1 Ribonucleotide binding
MARK1 MAP/microtubule affinity-regulating kinase 1 -2.42785 0.016744 hypomethylation 1 Nucleotide binding, protein kinase cascade, protein amino acid phosphorylation, intracellular signalling cascade, microtubule cytoskeleton, protein kinase activity, phosphotransferase activity, alcohol group as acceptor
FAM13B Family with sequence similarity 13, member B -2.41743 0.006546 hypomethylation 5 GTPase activator activity
ATM Ataxia telangiectasia mutated -2.41147 0.020951 hypomethylation 11 Purine ribonucleotide binding, ribonucleotide binding, nucleotide binding, protein amino acid phosphorylation, intracellular signalling cascade, microtubule cytoskeleton,
NPAT Nuclear protein, ataxia-telangiectasia locus -2.40925 0.020950 hypomethylation 11  
SDCCAG10 CWC27 spliceosome-associated protein homolog (S. cerevisiae) -2.39996 0.004538 hypomethylation 5  
RSBN1 Round spermatid basic protein 1 -2.38842 0.016944 hypomethylation 1  
MED13 Mediator complex subunit 13 -2.32252 0.009664 hypomethylation 17 VitaminD receptor binding, intracellular signalling cascade,
MATN2 Matriline 2 -2.31173 0.021316 hypomethylation 8  
RAD51 RAD51 recombinase -2.28733 0.025275 hypomethylation 15 Purine ribonucleotide binding, ribonucleotide binding, nucleotide binding,
SLC4A5 Solute carrier family 4 (sodium bicarbonate cotransporter), member 5 -2.27009 0.015108 hypomethylation 2 Anion transmembrane transporter activity,
WBSCR17 Williams-Beuren syndrome chromosome region 17 -2.26845 0.015743 hypomethylation 7  
RBM25 RNA binding motif protein 25 -2.24768 0.046929 hypomethylation 14 Ribonucleotide binding, nucleotide binding,
DOCK4 Dedicator of cytokinesis 4 -2.22303 0.023445 hypomethylation 7 Rho GTPase binding, RacGTPase activator activity, RacGTPase binding,
CCDC148 Coiled-coil domain containing 148 -2.19913 0.014485 hypomethylation 2  
PHF19 PHD finger protein 19 -2.19496 0.010693 hypomethylation 9  
RPS6KA2 Ribosomal protein S6 kinase, 90kDa, polypeptide 2 -2.19420 0.004795 hypomethylation 6 Proteinkinase cascade, protein amino acid phosphorylation, intracellular signalling cascade, proteinserine/threonine kinase activity
CTSO Cathepsin O -2.18726 0.035781 hypomethylation 4  
STK17B Serine/threonine kinase 17b (apoptosis-inducing) -2.18165 0.029008 hypomethylation 2 Proteinserine/threonine kinase activity, protein kinase activity, phosphotransferase activity, alcohol group as acceptor
SGK1 Serum glucocorticoid regulated kinase 1 -2.14645 0.013318 hypomethylation 6 Phosphotransferase activity, alcohol group as acceptor, protein amino acid phosphorylation
HLA-C Major histocompatibility complex, class I, C -2.13388 0.006649 hypomethylation 6 MHC class II receptor activity
C20orf3 Chromosome 3 open reading frame, human -2.13244 0.025289 hypomethylation 20  
HLA-C   -2.12459 0.027134 hypomethylation 6 MHC class II receptor activity
ATP13A3 ATPase type 13A3 -2.12378 0.047204 hypomethylation 3 Nucleotide biosynthetic process, purine nucleotide biosynthetic process,
PHF12 PHD finger protein 12 -2.10335 0.024860 hypomethylation 17  
A2BP1 RNA binding protein, fox-1 homolog (C. elegans) 1 -2.10170 0.000697 hypomethylation 16  
MCC Mutatedin colorectal cancers -2.09595 0.028307 hypomethylation 5  
ANKH ANKH inorganic pyrophosphate transport regulator -2.07819 0.041987 hypomethylation 5 Locomotory behaviour, regulation of bone mineralization, inorganic anion transmembrane transporter activity
ERICH1 Glutamate-rich 1 -2.07436 0.013699 hypomethylation 8  
PHC3 Polyhomeotichomolog 3 (Drosophila) -2.05013 0.016319 hypomethylation 3  
LOC404266   -2.04836 0.018899 hypomethylation 17  
HOXB5 HomeoboxB5 -2.04707 0.018899 hypomethylation 17  
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 -2.04293 0.022498 hypomethylation 6  
CRIM1 Cysteine rich transmembrane BMP regulator 1 (chordin-like) -2.04276 0.030130 hypomethylation 2 Proteinkinase activity,
AMACR Alpha-methylacyl-CoA racemase -2.04223 0.015920 hypomethylation 5  
ASNA1 arsAarsenite transporter, ATP-binding, homolog 1 (bacterial) -2.03930 0.010834 hypomethylation 19 Inorganic anion transmembrane transporter activity
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 -2.03728 0.040322 hypomethylation 15 GTPase activator activity,
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 -2.03695 0.020507 hypomethylation 7 Oxidation reduction, mitochondrial respiratory chain, respiratory chain,
UNC84A Sad1 and UNC84 domain containing 1 -2.03190 0.000411 hypomethylation 7  
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -2.02822 0.042294 hypomethylation 10 Ribonucleotide binding,
OXA1L Oxidase (cytochrome c) assembly 1-like 2.00760 0.034505 hypomethylation 14 Oxidation reduction, negative regulation of ATPase activity, proton-transporting two-sector ATPase complex assembly, mitochondrial respiratory chain complex assembly, aerobic respiration, negative regulation of hydrolase activity, cellular macromolecule localization, cellular protein localization
GMNN Geminin, DNA replication inhibitor 2.02374 0.012055 hypomethylation 6 Negative regulation of DNA replication, nuclear export, Cajal body
LSG1 Large60S subunit nuclear export GTPase 1 2.07421 0.019916 hypermethylation 3  
NUDT1 Nudix (nucleoside diphosphate linked moiety X)-type motif 1 2.11897 0.002342 hypermethylation 7  
FTSJ2 FtsJ RNA methyltransferase homolog 2 (E. coli) 2.12453 0.002342 hypermethylation 7  
HLA-DQB1 Majorhistocompatibility complex, class II, DQ beta 1 2.29574 0.033972 hypermethylation 6 MHC class II receptor activity
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 2.32516 0.033508 hypermethylation 5  
MED12L Mediator complex subunit 12-like: 2.40530 0.033766 hypermethylation 3  
GPR171 G protein-coupled receptor 171 2.42853 0.033766 hypermethylation 3  
TEX14 Testis expressed 14 3.09392 0.035419 hypermethylation 17 Protein amino acid phosphorylation, protein kinase activity, transferase activity, transferring phosphorus-containing groups
RAD51C RAD51 paralog C 3.47220 0.035419 hypermethylation 17 Purine ribonucleotide binding
MYCBP MYC binding protein;  3.52884 0.000838 hypermethylation 1  
GJA9 Gap junction protein, alpha 9, 59kDa 3.95041 0.000838 hypermethylation 1  
LIPT1 Lipoyl transferase1 5.93865 0.029695 hypermethylation 2  
TSGA10 Testis specific, 10 -6.01644 0.029695 Hypermethylation 2  
DGKQ Diacylglycerol kinase, theta 110kDa -3.66709 0.013574 Hypermethylation 4 Proteinkinase cascade, intracellular signalling cascade
FMN2 formin 2 -3.55680 0.019258 Hypermethylation 1 Establishment of spindle localization, metaphase, cytokinesis during cell cycle, establishment of chromosome localization, intracellular signalling cascade
C1orf52 Chromosome1 open reading frame 52 -3.34680 0.015531 Hypermethylation 1  
PSMD2 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -3.31289 0.023962 Hypermethylation 3 Proteasome regulatory particle
DGKQ Diacylglycerol kinase, theta 110kDa -3.26934 0.016689 hypermethylation 4 Protein kinase cascade, intracellular signalling cascade
Table 1: A list of genes with differential methylated regions in the patient group.