Figure 3: 5-FU/distilled water treated group: On day 8, 5-FU caused mucosal damage in the jejunum. It cause blunting of villi, they appear short and broad and sometimes missing (A1, H&E ×40), some of the absorbing cells are lost in some area, arrow (A2, H&E×100), and the goblet cells are markedly decreased in number with infiltration of inflammatory cells in the lamina propria, arrow (A3, H&E ×400), muscular edema and congested blood vessels also can be seen, arrow (A4, Trichrome ×400). On day 12, the villi of jejunum restore it shape (B1,Trichrome ×40; B2,Trichrome ×100), they are nearly intact and completely covered by tall columnar cells (B3, H&E ×400). Nearly intact crypts with normal epithelial lining are also observed, but congested blood vessels also can be seen, arrow (B4, Trichrome ×400). Negative and moderate Ki-67 immuno reactivity in nuclei of cells at day eight and twelve respectively (C1, immunohistochemistry ×100, C2, immunohistochemistry ×400). Negative and moderate cytoplasmic reaction to Bcl-2 cells at day eight and twelve respectively (C3 immunohistochemistry ×400, C4, immunohistochemistry ×400).