| |
Gr1highCD11b+ cells |
Gr1lowCD11b+ cells |
| Expression levels (spleen) |
Elevated in males
4-26 weeks of age |
Elevated in females
(>9 wks) |
| Immunosuppressive in vitro |
Yes (females only <16 wk) |
Yes (females only <9 wk) |
| Cellular target |
B cell differentiation |
T cell differentiation and proliferation |
| Cell-Cell contact |
No (males);
Yes (females) |
ns* |
| Effector mechanism |
Unknown (males);
ROS/NO (females) |
ns* |
| Immunostimulatory in vitro |
No |
Yes (female ≥ 9wk old; males >16 wk old) |
| Cellular target |
n/a |
B cell differentiation and T cell proliferation |
| |
All Gr1+ cells |
| Immunosuppressive in vivo |
Yes (males) |
No (females ≥ 9 wks of age) |
| Cellular target |
GC reaction via control of TFH cell differentiation (males) |
n/a |
| *ns: not studied; n/a: not applicable [13,28] |
