ID Protein name UniProt Accession Sequence P value
ACM1_421_433 Muscarinic acetylcholine receptor M1 P11229 CNKAFRDTFRLLL 0.046
ACM4_456_468 Muscarinic acetylcholine receptor M4 P08173 CNATFKKTFRHLL 0.015
ACM5_498_510 Muscarinic acetylcholine receptor M5 P08912 CNRTFRKTFKMLL 0.032
ADDB_696_708 Beta-adducin P35612 GSPSKSPSKKKKK 0.022
CDK7_163_175 * # Cell division protein kinase 7 P50613 GSPNRAYTHQVVT 0.032
CSK21_355_367 Casein kinase II subunit alpha P68400 ISSVPTPSPLGPL 0.018
FOXO3_25_37 * Forkhead box protein O3 O43524 QSRPRSCTWPLQR 0.015
H32_3_18 * # Histone H3.2 Q71DI3 RTKQTARKSTGGKAPR 0.045
INSR_1368_1380 * # Insulin receptor precursor P06213 KKNGRILTLPRSN 0.032
MP2K1_287_299 Dual specificity mitogen-activated protein kinase kinase 1 Q02750 PPRPRTPGRPLSS 0.022
P53_308_323 Cellular tumor antigen p53 P04637 LPNNTSSSPQPKKKPL 0.038
* Peptides showing increased phosphorylation by human recombinant IRAK-4 (0.1 μg)
# Peptides phosphorylated by human recombinant IRAK-4 (0.1 μg) showing decreased (>50%) phosphorylation in the presence of 2500 nM IRAK-1/4 inhibitor I
Table 3: Peptides on PamChip showing significant increase in phosphorylation by protein lysates derived from AD temporal cortex compared to control temporal cortex. P values indicate significant differences between control and AD cases. Peptides that are potentially phosphorylated by IRAK-4 are shown as indicated.