Figure 11: MIP treatment suppresses tumor growth and induces a Th1 cytokine response. (a) General outline of the in vivo experiment protocol. (b) Comparison of the anti-tumor effects of MIP administered at different time points. Cohorts of ten mice were inoculated s.c. with ~107 Sp2/0 cells. Mice were injected i.d. with a single dose of MIP (~5×108) either one day (-1D) before or 3 (+3D) or 6 (+6D) days after tumor inoculation. Mice injected i.d. with PBS on day 3 were included as controls. The growth of tumors (mean ± SD mm3) at indicated days post implantation. (c) Representative photographs of solid tumors from different treatment groups dissected on day 14 [43].