Figure 2: Lymphatic network in LNs at steady-state and in inflammation. (A) Steady-state condition: The lymphatic network in LNs is organized into the subcapsular sinus (SCS), the medullary sinus (MS) and the cortical sinuses (CS). B cell areas (blue) and T cell zones (green) are shown. (B) Inflammation leads to a massive expansion of the SCS, MS and CS. Pro-lymphangiogenic (+) and anti-lymphangiogenic (-) factors produced by B and T cells respectively, impact the strength of the LN lymphangiogenic response.