Figure 1: Saline/distilled water treated group: In the two studied periods, day 8 (A) and day 12 (B), the dorsal surface of tongue exhibited sharp conical projections of regular filiform papillae with pointed tips. The connective tissue consists of dense fibers and muscles (A, H & E x100). Well-formed fungiform papillae are observed with broader surface and a single well defined barrel like taste bud seen in each papilla (B, H & E x400). Moderate Ki-67 immuno reactivity in nuclei of basal cells (arrows) and taste bud (C1, immunohistochemistry ×400). Mild cytoplasmic reaction to Bcl-2 in tongue epithelium (arrows) (C2, immunohistochemistry ×400).