| Renal lymphatics within the normal kidney run in proximity to larger vessels. Their number decreases in the outer cortex. Glomerula and normal medulla do not contain lymphatics |
| Pro-lymphangiogenic factors are expressed by infiltrating mononuclear cells and tubuloepithelial cells |
| Models of renal fibrosis and data from human renal diseases illustrate neolymphangiogenesis in progressive renal diseases |
| Lymphangiogenesis in renal allografts might be detrimental, whereas in other chronic kidney diseases the functional role remains to be defined |
| A booming area of studies is the interaction between pro-lymphangiogenic factors and fibrogenic growth factors |
| Studies are needed concerning the therapeutic impact of the blockade of lymphangiogenesis in models of renal disease and renal allograft rejection |
