Figure 2: Differential levels of immune markers in A53T brain and blood. Histograms represent levels of A) pro-inflammatory cytokines IL-1α, IL-1β, IL-6 and TNF-α in the brain and total blood of A53T mice, B) anti-inflammatory cytokines IL-4 and IL-10, C) modulators of immune memory IL-2 and IL3, D) VEGF and IFN-γ and E) chemokines CCL2, CCL5 and CX3CL1. n=4 for each strain at each time point. ANOVA, Neuman Keuls, Mean ±, * indicates significantly different than WT with p<0.05, **p<0.01, ***p<0.001. Histograms represent ELISA levels of F) α-Synuclein and p-Tau and G) caspase-3 activity in the brain of A53T mice treated I.P with 10 mg/kg nilotinib or 5 mg/kg bosutinib or 3 μL DMSO every other day for 6 weeks. n=4 for each strain at each time point. ANOVA, Neuman Keuls, Mean ±, * indicates significantly different than WT with p<0.05, **p<0.01, ***p<0.001.